• Thursday , 16 August 2018

Prozac VS Zoloft

Perhaps all patients who have experienced serious cases of depression know that Prozac and Zoloft are one of the most powerful remedies for treating it. Prozac vs. Zoloft is an old confrontation, but is it possible to decide which drug is better? Both drugs do their job well; have many similarities, and some differences. In what cases are they better taken? Let’s consider this issue in more detail.Prozac VS Zoloft

Effects of drugs

Prozac acts on the basis of Fluoxetine, while the main active ingredient of Zoloft is Sertraline. Sertraline influences the process of seizure of serotonin, which contributes to the cure of depressive conditions. Fluoxetine not so long ago gained popularity as well as an unofficial drug for combating obesity, because one of its side effects is a lack of appetite. Nevertheless, doctors strongly recommend not using Prozac for this purpose and treating them only with depressive conditions, obsessive-compulsive disorder, and nervous bulimia, but under the strict supervision of a doctor.

Zoloft has a slightly wider range of action: for example, it is also used for the treatment of social phobia, panic attacks for their relief and in post-traumatic depression. Zoloft is not used to treat eating disorders because it does not have such indications.

Form of issue and reception

Both drugs are available in the form of tablets, but they have a different dosage of the active substance. Immediately after taking the pills begin to act, but Prozac and Zoloft are used for long-term treatment. The patient may take 20 to 60 mg of Prozac per day, depending on the severity and type of the disease. In rare cases, this dose can be increased to 80 mg when agreed with a doctor. In this case, dose adjustment is required if the patient takes other drugs in parallel or has liver problems, since liver health is important for the treatment of this drug.

With regard to Zoloft, in a day, it is allowed to take 50 to 200 mg of the drug. In this case, the lowest possible dose is considered to be the most effective, since with this mode of administration the drug does not cause addiction and tolerance to the components. 

Side effects

Some of the basic side effects of Prozac and Zoloft are almost identical. These include:

  • headache
  • dry mouth
  • nausea and vomiting
  • problems with libido
  • bleeding, etc.

Rarer and more dangerous side effects will be:

  • loss of consciousness
  • impaired coordination of movements
  • convulsions.

As already mentioned above, Prozac provokes violation of appetite, can lead to a decrease in body weight. As a result, women may have problems with the menstrual cycle and vaginal bleeding. In this case, you need to see a doctor for help, because this symptom is serious enough and can lead to undesirable consequences.

Both drugs can cause an allergic reaction. Allergy manifests itself in the form of edema, shortness of breath, itching, rash and other skin troubles. In case of detection of allergies, it is recommended to stop taking the drug and consult a doctor about the question of replacing the medicine with an analog. Remember that Prozac and Zoloft are not analogues of each other and cannot be interchangeably without preparation. Joint taking of two drugs can cause severe side effects.

Drugs comparisons


Prozac and Zoloft are not used to treat children and pregnant women, in rare cases Zoloft can be used in pediatrics for children over 6 years of age. It is also forbidden to use if there is an allergy to the main components. Prozac or Zoloft cannot be used to treat patients who are already taking inhibitors. Caution is advised to use these medications to treat patients in old age, as well as those patients who have pronounced depressive symptoms, such as suicidal thoughts or attempts to commit suicide. Both drugs can aggravate the patient’s condition. 


Prozac and Zoloft are similar in many respects. These are drugs that affect the seizure of serotonin in the body, so they are most often used to treat depression and psychological disorders. Nevertheless, the abundance of side effects and an impressive dose of active substance in each of the medicines allow saying with certainty that the joint use of drugs is very dangerous. If you think that one of these drugs suits you or isn’t suit you, you should first consult with your doctor. Self-administration of potent drugs is very dangerous, so take care in advance about the adjustment of the dose and duration of treatment.

Prozac VS Zoloft Dr H. Scheele
Author Review



Related Products