• Thursday , 16 August 2018

Meridia (Sibutramine)

Meridia (Sibutramine) Dr H. Scheele
Drug Review



Generic Name: Sibutramine (si BUE tra meen)
Brand Names: Meridia
Dosage: 10mg, 15mg
Generic Meridia is known as a preparation that helps people lose weight due to its influence upon the brain center that regulates appetite control. Meridia is also known by the name of its active material, which is called sibutramine.

Meridia is a prescription drug, so you would not be able to buy sibutramine online without a prescription in a number of countries. This medicine is also included in the list of prohibited substances made by World Anti-Doping Agency. Thus, the use of the drug is prohibited during sporting events.

It is claimed that 20 thousand volunteer from every corner of the world took part in clinical trials of Meridia. No severe side reactions have been found.

Generic Meridia usually comes in form of solid gelatinous capsules with yellow coats, containing white or almost white dry powder. There are websites that offer to buy sibutramine online for a cheap price.

Pharmacological action of Meridia

When generic sibutramine is introduced into the human body, bloodstream helps it penetrate into the cerebrum, leading to the decreased appetite.

As a rule, there is no feeling of hunger, because a patient experiences the reduction of nutritional requirement by approximately 30%.

The metabolization of Meridia happens at the same time when pharmacologically active agents are formed in human organism. The metabolites of sibutramine are responsible for the inhibition of peculiar monoamines. This process enlarges the content of these monoamines (serotonin and noradrenaline) in synapses; it also increases the activity of 5-ht serotonin and central adrenergic receptors. Thus, generic Meridia:

  1. Increases thermal production
  2. Reduces the nutritional requirement
  3. Facilitates the process of increasing the satiety

The decrease of body weight, caused by Meridia, is accompanied by favorable changes of lipidic profile and glucose level in blood plasma.

In what case Meridia can be prescribed?

Alimentary obesity is the main reason why doctors prescribe Meridiafor patients ― usually as a means of maintenance therapy.

There are some additional merits of this pharmaceutical:

  1. Therapy with this drug improves food digestion
  2. Haemoglobin quality becomes better
  3. Sugar and fatty acids, which are contained in blood, get normalized

There are specific indices that might lead to the prescription of sibutramine:

  • Patient’s body weight totals higher than 30 kg per m2
  • Patient’s body weight totals higher than 27 kg per m2, and overweight implies that there could be additional risk factors

Medics considers type two pancreatic diabetes and lipid metabolism abnormalities as risk factors, mentioned in the second clause.

What are the adverse reactions to taking Meridia?

Sibutramine is characterized by quite good tolerance. Side reactions development can be experienced during the first few week of the course of treatment. As a rule, most negative effects are ill-defined and are over without the discontinuation of therapy or some peculiar treatment.

Most common side effects happen on the side of central nervous system. These are:

  • Headaches
  • Giddiness
  • Somnipathy
  • Paresthesia
  • Anxieties

Other symptoms are also possible:

  1. Cardiovascular system: hypertension, tachycardia, palpitation, vasodilation, dermahemia, cardiac fibrillation.
  2. Digestive system: often ― nausea, hemorrhoids exacerbation.
  3. Immune system: allergic hypersensitivity reaction (from mild skin rash appearance, itching, and nettle rash to anaphylactic reaction and angioneurotic edema).

What are the contraindications toMeridia?

Individuals who suffer the intolerance towards the active material or other components of this pharmaceutical, as well as patients with inherited lactose intolerance, should not take Meridia without a prescription.

Angle-closure glaucoma, apparent hepatic and renal dysfunctions, hyperthyroidism, pheochromocytoma, and non-malignant hypertrophy with urinary retention imply that people suffering one of these illnesses are not allowed to take Meridia without a prescription.

What is overdose with Meridia characterized by?

Big dosage of Meridia usually results in the development of adverse reactions. These include headaches, arterial hypertension, giddiness, and tachycardia.

Being overdosed, a patient should receive medical aid, which includes gastric lavage and enterosorbents administration in 60 minutes after the overdose. He or she should be taken under surveillance for at least 24 hours.

What if I have missed a dose?

Missing a dose of this pharmaceutical does not make much difference. Do not try to compensate it and take double dose next time: this is not recommended by doctors. You should better keep taking the drug according to your schedule and forget about the missed intake.

How to buy Meridia online

A number of online pharmacies allow Internet users to make purchases of cheap pharmaceutical products (including Meridia for sale). Nevertheless, it is reasonable to check your local law before buying anything in these online drugstores.

In case the laws of your state allow you to buy Meridia online, you can take advantage of these websites and order a cheaper analog of the drug you need. Some of these pharmacies even offer overnight delivery. You just need to make sure that the drugstore you are going to buy it has an impeccable reputation. Remember that there are deliberate criminals that might sell you counterfeit production, so be careful where you purchase!

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