• Thursday , 16 August 2018

Provigil (Modafinil)

Provigil (Modafinil) Dr H. Scheele
Drug Review



Generic Name: Modafinil
Brand Names: Provigil
Dosage: 200mg
Provigil is a pharmaceutical of analeptic class. Its main objective lies in affecting centers of medulla oblongata so that the vital functions of breathing and blood circulation gain stimulation. To put it in simple terms, this medicine invigorates you.

This preparation is widely known under its generic name, which is modafinil. The latter is often prescribed for people who suffer narcolepsy and attention deficit disorder, along with Adderall and Ritalin. However, generic modafinil is frequently used as cognitive capacity intensifier.

There is a story about USAF pilots: one day, they supposedly took 600 milligrams of modafinil to spend 40 hours without a sleep. Nevertheless, their reaction and accuracy rates remained practically on the same level.

Uses and dosage of generic modafinil

The standard dosage is 100-200 mg or 4 mg per one kilogram of person’s weight. It is usually taken when:

  1. There is a need of purposeful and harmless sleep suppression
  2. The cheerful state is required after a sleep (e.g. in the morning)

Clinical application implies that recommended doses are from 200 to 400 mg per day. Such dosage is usually prescribed to treat:

  • Excessive daytime sleepiness (connected with narcolepsy)
  • Obstructive sleep apnoea

A patient can take a dose once per day (in the morning) or twice per day (in the morning and noon).

When used to increase the physical capacity for work, typical doses are between 100 mg and 400 mg. Modafinil is often used 2 or 3 hours before a sporting event. Keep in mind that the probability of adverse effects development might depend on the dosage.

Doctors often recommend starting with the minimal effective dose of modafinil, increasing it by 50 mg or 100 mg each taking until the optimal level will be established.

The range of generic Provigil’s application is enormous: basically, there could be any kind of sports that is concentrated upon aerobic load and powers of endurance. Modafinil also works perfectly for sportsmen that do strength or speed exercises with short interval between repetitions, such as shot put, pole-vaulting, or long jumps.

Some people consider modafinil as an effective workout stimulant.

Important information about taking modafinil

Be careful during the activities that require increased attention, for example, driving or operating the machinery. Avoid drinking alcohol under drug’s effect.

Safety precautions for modafinil

Provigil is not recommended for taking in case of some illnesses. If you suffer a heart disease that is called left ventricular hypertrophy, or have the history of inadequate reaction to stimulants (chest pains, cardiac rhythm disturbance), it is important to consult a physician before taking modafinil.

It is also vital to inform your MD about any current or past disease you have, especially:

  • Arterial tension increase
  • Cardiological issues (chest pains, myocardial infarction, heart valve disorder)
  • Hepatic dysfunction
  • Renal diseases
  • Mental and mood disturbance (manias, psychoses)
  • Regular usage or abuse of drugs or alcohol

Pregnant women should take modafinil only in case of extreme necessity. Doctor will help you determine the ratio between risk and benefit.

Pharmacological characteristic of modafinil

The half-life of Provigil is 13-15 hours, while its concentration in blood serum reaches 2 days after the first dose.

Clinical trials have shown that there are clear distinctions between modafinil and amphetamine, speaking about their influence on people. As opposed to amphetamine and methylphenidate influence (excessive cheerfulness), this active material makes selective effect on hypothalamus and amygdala.

When healthy people took 100-200 mg of modafinil 2 hours before an arithmetical test, they noticed the improvement of:

  • Memory capabilities
  • Visual planning
  • Speed of reaction

200 mg of modafinil were responsible for better short-term memory and information processing accuracy.

Apart from that, improvements were observed in general. People experienced the increased motivation and seemed to be really enjoyed with the work they had done.

What are the adverse reactions to modafinil?

Negative effects are usually connected with the stimulation of central nervous system functioning. They might include:

  • Personality changes
  • Agitation
  • Euphoria
  • Shivering
  • Sleeplessness
  • Nervousness

There could also be such gastrointestinal disturbances as:

  1. Anorexia
  2. Xerostomia
  3. Stomachache
  4. Nausea

Other side reactions might include abnormal cardiac rhythm, palpitation, and hypertension.

In rare instances, Provigil might cause voluntary movement abnormalities, increased alkaline phosphatase, and serum rash.

What are the signs of overdose with modafinil?

James McGough, a psychiatrist of The University of California argues that the consequences of an overdose with Provigil are the same as with coffee: nervousness and stomachache.

Other symptoms might include highly nervous state, palpitation, and hypertension. If you think you have overdosed the drug, seek for medical advice as soon as possible.

Can I buy modafinil online without prescription?

You need to check it with your local law. Perhaps, your country allows you to buy Provigil online without prescription.

If yes, you can easily find cheap modafinil in a number of online pharmacies, where you can get an overnight delivery.