• Thursday , 14 December 2017

Viagra (Sildenafil)

Viagra (Sildenafil) Dr H. Scheele
Drug Review

Summary:

5

Generic Name: Sildenafil
Brand Names: Viagra
Dosage: 25mg, 50mg, 100mg
Generic Viagra is a widely used aphrodisiac that gained its popularity as a cure for sexual drive derangement. It is also known by the name of its active material, which is sildenafil. This pharmaceutical helps men achieve the erection and keep it with sexual excitement. The action is symptomatic and, as a matter of fact, Viagra does not “treat” male erectile disorder.

Uses of generic Viagra

Doctors prescribe sildenafil when a patient suffers erectile disorder. The latter reveals in incapacity of attaining and keeping up the erection that is required for a successful sexual intercourse. A patient should take Viagra when being sexually excited.

Adult males (older than 18) follow the recommendation to take Viagra in dose of 50 mg. A dose usually needs to be taken one hour before the sexual activity. The preparation is considered to be efficient and has good tolerance, so the dosage might be either decreased to 25 mg or increased to 100 mg. The latter is a recommended maximum dose. Generic sildenafil should not be used more often than once per day. As experience has shown, the efficiency of the drug increases when taking it with food, as compared to taking on an empty stomach.

Before the treatment with Viagra, a patient needs to undergo a full medical examination in order to determine possible reasons or erectile disorder.

Pharmacological action of Viagra

The medication helps men normalize the erection due to its influence on natural enzymes, which take part in sexual arousal realization. A considerable amount of nitrogen oxide is produced in process of sexual excitement. It dilates the vessels and increases blood flow to penis cavernous bodies. However, nitrogen oxide affects vessels not on its own, but with the activation of secondary mediator, which is known as cyclical guanosine monophosphate. The active material inhibits the activity of enzyme that destroys the molecule of cyclical guanosine monophosphate. Thus, its action lasts longer, vessels stay dilated longer as well, which results in normal erection.

In what cases is Viagra without prescription counter-indicative?

Viagra is contra-indicated when a patient is hyper-susceptible towards the drug components. The preparations for erectile disorder therapy are not supposed to be taken if sexual activity is not recommended for a person. It applies to the cases of:

  1. Acute cardiac decompensation
  2. Instable angina pectoris

 Women and persons under 18 years old should avoid using Viagra.

This medication is also counter-indicative for all the patients who have lost their vision due to ischemic neuropathy of cranial nerve.

Apart from that, Viagra should not be prescribed for patients who suffer:

  • Known inherited degenerative retina diseases (for example, pigmented retinitis)
  • Acute compromised liver function
  • Recent myocardial infarction or stroke
  • Arterial hypotension (when arterial pressure is lower than 90/50 mm of mercury)

Pharmaceuticals that help in erectile dysfunction therapy should be used with caution when a patient have anatomic penis deformation (Peyronie’s disease, angulation, cavernous fibrosis). The same applies to patients with priapism tendency (leukemia, drepancytic anemia, plasma cell myeloma).

How does Viagra interact with other drugs and alcohol?

The patient’s blood plasma would have increased sildenafil level if a patient also took:

  • Ketoconazole
  • Cimetidinum
  • Erythromycin

The clearance reduction would also be expected. In combination with natrium nitroprusside, Viagra increases its antiaggregantic effect. This medicine also intensifies the hypotensive action of nitrates when combined. Be extremely aware about such interaction, because it might lead to fatal outcome. The simultaneous taking of sildenafil with hypoglycemic perioral pharmaceuticals, calcium channel-blocking agents, and beta-adrenergic blocking agents is life-threatening as well.

Are there any adverse reactions to Viagra?

Below you can find some side reactions that might develop while taking Viagra:

  • Gastric indigestion
  • Stuffiness in nose
  • Feeling of flush
  • Color perception disturbance
  • Blurred vision
  • Somnolence
  • Skin sensitivity reduction
  • Giddiness
  • Ear noise
  • Headache

Rarer instances also include:

  1. Nose bleeding
  2. Hypersensitivity reaction development
  3. Hypotension
  4. Hypertension

There has been observed that sometimes patients might experience muscular ache, increased fatigability, increased cardiac rhythm, skin eruption, vomiting, and dry mouth when taking Viagra without prescription.

What happens in case of overdose with Viagra?

Medical investigations have shown that sildenafil overdose leads to the more evident adverse reactions. This case requires symptomatic therapy as a treatment. Dialysis is considered to be inefficient, as the active material gets connected with plasma proteins rather actively and quickly.  

Can I buy sildenafil online legally?

The answer is “yes”. There is a great number of online pharmacies that allow you to place an order and get your overnight delivery of cheap Viagra. That being said, you should be aware of counterfeit products. It is always better to do a little research about the pharmacy before buying pharmaceuticals.

How to buy Viagra online without prescription?

You can find Viagra for sale in various online drugstores. The procedure is quite simple and similar to making other purchases online: you select your item and its quantity, add it to the card, then decide on which payment method you’d like to use (PayPal, etc.), and place an order.

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