• Thursday , 16 August 2018

Zoloft (Sertraline)

Zoloft (Sertraline) Dr H. Scheele
Drug Review



Generic Name: Sertraline
Brand Names: Zoloft
Dosage: 25mg, 50mg, 100mg
Generic Zoloft is a popular pharmaceutical intended to treat chronic or initial cases of depression. It is notable for not causing dependency on drug or increasing body weight given that it has been taken for a long time.

Zoloft is also known by the name of its active component, which is sertraline. The latter does not have much influence on dopamine or norepinephrine reuptake.

Taking into account that generic sertraline is used in therapeutic dosage, this active material is responsible for 5-hydroxytryptamine reuptake inhibition in human thrombocytes. Zoloft does not make anticholinergic, stimulatory, or sedative effect. This pharmaceutical does not cause the intensification of adrenergic activity.

Some countries do not allow the distribution of Zoloft without a prescription. That being said, other states might permit online pharmacies offering generic Zoloft for sale. Always consider consulting your physician instead of self-treatment.

Uses of generic Zoloft

Doctors usually prescribe sertraline to treat the following illnesses:

  • Social phobias
  • Manic state depressions
  • Obsessive-compulsive disorders
  • Depressions with apprehensive feelings
  • Posttraumatic depressive disorders
  • Panic disorders with agoraphobia

Another use include prescribing Zoloft as a remedy for recurrence prophylaxis. The continuation of treatment makes it possible to prevent recurrences of depression initial episodes. It also applies to their future development.

Pharmacological action of Zoloft without a prescription

Serotonergic transmission is increased when the 5-hydroxytryptamine reuptake is inhibited. As a result, adrenoceptive activity subsequently happens to be inhibited in locus coeruleus. Sertraline is also responsible for the inhibition of serotonin neuron stimulation in and around myelencephalon. It results in the increased activity of locus coeruleus. Subsequently, presynaptic alpha-2 adrenergic receptors become less active. The same applies to postsynapticbeta-adrenergic receptors.

Zoloft is considered to be a preparation that does not form a habit. Psychomotor activity experience no changes. Pharmaceutical does not cause cardiotoxic, awareness-inducing, anticholinergic, or sedative effect. The active material does not make the sympathetic nervous system less active because of serotonin reuptake selective inhibition.

The development of initial effect supposedly takes about a week. The full effect of Zoloftusually comes after two weeks or later.

What are the adverse reactions to Zoloft?

The most common negative effects to sertraline usually are the following:

  • Anorexia
  • Bleeding (nose bleeding included)
  • Palpitation
  • Xerostomia
  • Allergic reactions

Doctors consider these side effects as less frequent:

  1. Abdominal spasms
  2. Vomiting
  3. Tympanism
  4. Hallucinations
  5. Unstable stool
  6. Body weight loss
  7. Sickness
  8. Appetite increase
  9. Diarrhea
  10. Tremor
  11. Akathisia
  12. Giddiness
  13. Sleeplessness
  14. Paresthesia
  15. Headache
  16. Depression symptoms
  17. Dermahemia
  18. Somnolence
  19. Aggressiveness

Traditionally, adverse reactions are treated by cardiac and hepatic functions control, gastric lavage, airways patency ensuring (which includes the pulmonary ventilation and oxygenation), and emetic drugs prescription.

Some methods are identified as ineffective. These are replacement blood transfusion, artificial diuresis, hemoperfusion, and dialysis.

Zoloft contraindications

Zoloft is counter-indicative to those who are hypersensitive towards the medication. The concomitant use of this drug with monoamine oxidase inhibitors is contraindicated as well.

What are the symptoms of overdose with Zoloft without a prescription?

An overdose with Zoloft is typically followed by increased adverse reactions. Most commonly, these are tachycardia, vomiting, nausea, tremor, agitation, and comatose state.

You would need to seek for emergency medical aid if you experience concerning symptoms. Resuscitative measures are required.

There have been cases of taking 13,5 grams of sertraline without a fatal outcome. The latter might happen only in case of concomitant use of Zoloft with alcohol and/or other pharmaceuticals.

How does Zoloft interact with other preparations?

There have been cases of severe side effects (up to fatal) when people combined Zoloft with monoamine oxidase inhibitors, particularly the selective monoamine oxidase inhibitorselegiline. Some cases have demonstrated the serotonergic syndrome with such symptoms as vegetative dysfunction, hyperthermia, rigidity, and myoclonus.

If a patient uses 200 mg of Zoloft per day, it does not potentize the effects of alcohol, carbamazepine, haloperidol, or phenytoin in respect of cognitive or psychomotor functions in healthy individuals. That being said, it is not recommended to take this medicine with alcohol at the same time.

How to buy sertraline online legally?

Many online pharmacies provide their customers with an ability to purchase cheap drugs. Some of them even offer an overnight delivery. On the other hand, it might be prohibited to buy Zoloft online in your country. To avoid legal issues, you need to check your local law.